Abstract: An anticancer “magic bullet” should have both efficacy and specificity parts. We have used an effective Apoptosis Inducer to trigger the apoptosis. Alpha-fetoprotein was used to deliver Apoptosis Inducers specifically to cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.
Constab Pharmaceutical Inc., MaRS Centre, Toronto, Canada